>oestradiol level on 0.03ml estradiol enanthate every 10 days...
considering my levels were at 9000pmol/L on just 4mg oral e i really think the universe doesn't want me to transition idk how to fix this :/
>oestradiol level on 0.03ml estradiol enanthate every 10 days...
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I take 0.10ml of the 50mg/ml EEn weekly and have seen amazing results below the face since adopting this regiment, and I can't cum anymore
So you have really low levels? Like 25pg/ml? You might be taking a cyp 3a4 inducer unaware. Should check if anything other drugs your taking is an inducer.
How many mg's are you injecting? You didn't list your vials dose...
no my levels are way WAY too high despite taking really low doses...
it's a 40mg/ml vial by the way from otoko
Assuming your vials is fine, are you taking any cyp 3a4 inhibitors? Otherwise your liver just doesn't produce a lot of cyp 3a4 enzymes, or some sort of liver disease.
But atleast your levels right now are not the worst thing ever. To high of levels isn't nearly as bad as to low. You should skip every other weeks injection. Between spacing your doses or using smaller, those are the only way to achieve lower levels.
im on 50mg bica as well
i have no fucking clue
my dose is literally the lowest it can go!!!
right before my next shot im not that dumb lol
so do i just inject like once a month instead of every 9 days???
>bica
do liver tests
done one 3 months and it looked fine should really do another one tho as im 8 n a 1/2 now
im only out to one person but they wouldn't go with me, idk i could go and make up some excuse about diagnosing gyno or something lol
the thing is nothing else was seemingly too high just the estrogen that's why im a bit concerned. im gonna talk with other ppl but i think at the moment im gonna let my levels drop and get a blood test unaffected by hrt instead of risking having high levels for even longer
so im injecting 1.2mg every 9 days
are you sure you're not injecting 0.3ml? seems too high for 0.03 which would be like nothing
definitely 0.03ml. my e levels at 0.15ml were approximately 5000pmol/L and while on 4mg oral e were 9000pmol/L, i really don't know what's happening and im struggling here 🙁
Yeah it sounds like a metabolic thing then, some people just don't break down estrogen very fast. You should be careful if you ever take opiates i think you would be very sensitive, and don't eat grapefruits either
Im kind of jealous. I wish I had that bad of a lacking of liver enzymes. I'd be high as fuck all day.
You would still build up tolerance, and some drugs would be weaker bc the metabolites are more potent than the actual drug but yeah it would be cheaper to stay happy lol
True. I guess it depends on the compound. But it'd always last longer. Nothing like getting sick between doses of methadone or suboxone before even 24 hour are up ×_×
>cheaper to stay happy
Yah! That's the spirit Bartender.
That sounds sucky ): I'm not having a good time rn because opiates are making my hyperprolactinemia worse but also life is hard
I was prescribed 4mg oral E and 100mg Spiro and I've had people telling me I'm going to be hon dosed.
How the fuck are we're your levels that high on pills? lol
Just lower your dose wtf, it literally makes your transition easier than most ppls
When did you get your levels checked? If it was anything besides "right before my next shot was due", the numbers are useless
This looks like the levels of someone who is taking a biotin supplement. Are you taking any multivitamins or hair supplements?
no no im taking nothing else besides bica daily
medicare finger prick tests
>medicare finger prick tests
That explains it
Thread over everyhon we figured it out
You need to do venous draws, fingerpricks are notoriously unreliable :v
Oh you should really pay the extra to get it done iv, the fingerprick ones are notoriously innacurate for hormones
Well i guess so, if you're on EEn the peak is like around 7-8 days, a lot of people do it every 2 weeks so you would theoretically be fine on longer
That's insane. Is that at trough? Are you using fingerprick tests?
how high is your testosterone?
apart from CYP3A4, there's also HSD17B2 which is responsible for inactivation of both estradiol and testosterone
ehm because im on bica on a blood test my T is slightly lower but not by much from male levels
consider 3 tests have came back with super high levels i don't think it's this
im a manmoder so im scared of getting blood drawn in person. im also considering coming off e for a couple weeks then testing my levels just on bica
>consider 3 tests have came back with super high levels i don't think it's this
I mean, that doesn't mean much, considering all 3 are fingerpricks that could've possibly been subject to the same contamination or irregularity causing ridiculous measurements. It's very common to have stupidly high measurements from fingerpricks.
Consider the logic of, you're somehow getting ridiculously supraphysiological Estradiol measurements after 9 days on 1.2mg EEn. And on top of that, you somehow only measured 800pmol more on 6mg vs 1.2mg. That really doesn't make sense.
>I'm a manmoder so I'm scared
aww you gotta be brave and also like they don't care. it's kinda a waste of money to keep doing it the other way not knowing if it's inaccurate /: are you out to anyone? would you feel better if someone went with you?
someone can explain this mystery?
test month after starting injections, trough, EV 7 mg/5 days - 703 pg/mL
test month after decreasing dose, trough, EV 5 mg/5 days - 726 pg/mL
test 2 months after decreasing dose, trough, EV 5 mg/5 days - 450 pg/mL
it really takes so long to reach full levels for me?
Umm you had full levels the first month? EV at these doses and frequency won't build up a whole lot. Like 2 weeks and the by the 3rd weak your usually at the highest it will go for the dose youve been using.
On average that is.
>Umm you had full levels the first month?
then why would i have even higher levels month after decreasing dose and lose them 2 months later?
i wonder what it means if i shift to enanthate. even slower build-up?
Probs just residual depot effect. Each injection will build a microcrystalline depot of medication that's slowly absorbed over time. Multiple shots will overlap.
We know that SQ has a similar pharmacokinetic profile to IM, so should result in the same phenomenon.
Everyone's metabolism re: cleavage will vary too, especially depending on injection site, which will affect absorption and subsequent elimination rate.
There's no too high aside from problem of tolerance and rising SHBG, boron 6-12mg day can fix SHGB issue and tolerance takes time develop (although happens faster due to crazy high levels), if you notice stalling in feminization/booba you may take one month breaks when you do only bica
all taking boron will do is increasing free testosterone and dihydrotestosterone. estrogen is bound very weakly
https://transfemscience.org/articles/shbg/
Would be neat to run a genetic test on you, I'm betting you have some kind of weird enzyme mutation
I have this same problem but also have lots of DHT I'm still masculinizing I don't know what to do
dutasteride, removes all sources of DHT
Bica stops DHT from attaching to receptors and masculinizing you
Fellow chad that gets high levels with low dose? Do you had little to no changes too?
very little chest growth (only small breast buds despite 8 and a half months hrt) and have no fat resdistro. my body and facial hair growth slowed down or became non existent on areas like my back n chest, and im pretty sure i look a bit more fem than starting but i feel like im not getting all potential changes. plus ive got super bad acne and i think it's the high levels because my skin was clear prior to starting hrt
I only had booba growth (unwanted) and stopping the progress of mpb as long as I take cypro, bica or duta (the best so far)
on bica currently but am considering just spending some time on bica alone.